中药药理与临床

附子在中医中运用较广,其主要活性成分为生物碱,其中脂溶性生物碱具有较强的心脏和神经毒性。附子水溶性生物碱的毒性较低,具有广泛的药理活性,如强心、抗炎、镇痛等。本文通过查阅近年来的研究,对附子的主要化学成分及近五年来的药理研究进行系统综述,为后续的深入研究提供参考。

Fuzi(附子) has been widely used in traditional Chinese medicine(TCM). Its main active components are alkaloids, among which the liposoluble alkaloids have strong cardiotoxicity and neurotoxicity. By contrast, the water-soluble alkaloids from Fuzi(附子) exhibit relatively low toxicity but extensive pharmacological activities, such as strengthening heart, anti-inflammation, and analgesia. This paper systematically reviewed the main chemical components and pharmacological studies of Fuzi(附子) identified in recent five years, in order to provide reference for further research.