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目的:对新疆特色药材一枝蒿进行质量标志物预测分析。方法:选用CNKI、万方、维普、中国生物医学文献数据库SinoMed、Pubmed、Web of Science等数据库检索一枝蒿、新疆一枝蒿和Artemisia rupestris L.的化学成分、药理作用和质量控制现状，并从植物亲缘性、传统功效及药性、成分可测性、入血成分、方剂配伍、网络药理学等方面对一枝蒿质量标志物(Q-marker)进行预测和分析。结果:一枝蒿中黄酮类、倍半萜类、挥发油类化合物均具备作为一枝蒿质量标志物的潜力。初步推测一枝蒿酮酸、一枝蒿酮酸B、一枝蒿酮酸C、一枝蒿酮酸E、一枝蒿酮酸F、山柰酚、紫花牡荆素、艾黄素等成分可作为一枝蒿的质量标志物。结论:为完善一枝蒿的质量评价体系及临床应用提供参考。
Abstract：Objective:To predict and analyze the quality markers of Artemisia rupestris L.,a native medicinal herb in Xinjiang. Methods:The chemical constituents, pharmacological effects, and quality control status of A. rupestris were reviewed based on the relevant articles retrieved from CNKI,Wanfang Data, VIP,SinoMed, Pubmed, and Web of Science with A. rupestris and A. rupestris in Xinjiang as the key words in the theme, title, abstract, and key words. The quality markers of A. rupestris were predicted from the aspects of plant affinity, traditional effects and medicinal properties, measurability of components, absorbed components, compatibility of prescriptions, and network pharmacology. Results:Flavonoids, sesquiterpenoids and volatile oils in A. rupestris have the potential to be used as quality markers. It is preliminarily predicted that rupestonic acid, rupestonic acid B,rupestonic acid C,rupestonic acid E,rupestonic acid F,kaempferol, casticin, and artemetin can be used as quality markers of A. rupestris. Conclusion:The findings provide reference for improving the quality evaluation system and clinical application of A. rupestris.
[1]赵宗政.新疆一枝蒿化学成分的研究[D].南京大学，2015.
[2]夏少立.一枝蒿乙酸乙酯部位的化学成分研究[D].安徽中医药大学，2020.
[3]崔凤侠，章宸，姜勇，等.新疆一枝蒿乙酸乙酯部位化学成分研究[J].中国中药杂志，2013,38(11):1757.
[4]张佩杰，曹妍，张珂，等.利用HPLC-IT-TOF-MS分析新疆一枝蒿的化学成分[J].中国中药杂志，2020,45(19):4658-4666
[5]Hou J,Dong H,Yan M,et al.New guaiane sesquiterpenes from Artemisia rupestris and their inhibitory effects on nitric oxide production[J].Bioorg Med Chem Lett,2014,24(18):4435-4438.
[6]He F,Aisa H A,Shakhidoyatov Kh M.Flavones from Artemisia rupestris[J].Chem Nat Compd,2012,48(4):685.
[7]Aisa H A,Zhao Y,He C X.A 2-phenoxychromone from Artemis- ia rupestris[J].Chem Nat Compd,2006,42(1):16.
[8]杨雨，杨秀梅，赵干，等.新疆野生及栽培一枝蒿多糖对树突状细胞免疫功能的影响[J].生物技术通报，2016,32(7):217-226.
[9]Zhang C,Liu B Y,Zeng K W,et al.New sesquiterpene and thiophene derivatives from Artemisia rupestris[J].Journal of Asian Natural Products Research,2015,17(12):1129-1136.
[10]Chen Z,Wang S,Zeng K W,et al.Rupestonic acids B-G,NO inhibitory sesquiterpenoids from Artemisia rupestris[J].Bioorg Med Chem Lett,2014,24(17):4318.
[11]Xiao J,Jiao F R,Zhao X,et al.Rupestonic acids H and I,two new sesquiterpenes from the flowers of Artemisia rupestris L[J].Phytochemistry Letters,2018:2778-2781.
[12]Xie Z Y,Lin T T,Yao M C,et al.Unusual guaiane sesquiterpenoids from Artemisia rupestris[J].Helv Chim Acta,2013,96(6):1182.
[13]Cao Y,Zang Y C,Huang X Y,et al.Chemical constituents from Artemisia rupestris and their neuraminidase inhibitory activity[J].Natural product research,2019,35(11):1-8.
[14]徐云.一枝蒿挥发油对过敏性鼻炎的作用研究[D].新疆医科大学，2017.
[15]文娜，曹雪琴，陈俊宇，等.顶空固相微萃取-气相色谱-质谱法测定新疆一枝蒿挥发性成分[J].湖北农业科学，2021,60(S1):329-331,339.
[16]姚小云.新疆一枝蒿挥发油组成及药理活性初探[D].乌鲁木齐：新疆大学，2013.
[17]贺飞.新疆一枝蒿化学成分及HPLC指纹谱图研究[J].北京：中国科学院研究生院，2012.
[18]Su Z,Wu H K,He F,et al.New guaipyridine sesquiter-pene alkaloids from Artemisia rupestris L.[J].HelvChim Acta,2010,93(1):33-38.
[19]He F,Nugroho A E,Wong C P,et al.Rupestines F-M,new guaipyridine sesquiterpene alkaloids from Artemisia rupestris[J].Chemical & Pharmaceutical Bulletin,2012,60(2):213-218.
[20]Abudurexiti A,He F,Sagdullaev S S,et al.Chemical Constituents of Artemisia rupestris[J].Chemistry of Natural Compounds,2017,53(2):371-372.
[21]毛艳，刘荣昌，丁曼，等.基于网络药理学和指纹图谱的一枝蒿抗乙肝病毒质量标志物预测分析[J].天然产物研究与开发，2022,34(5):864-873.
[22]白红进，赵小亮，万英.新疆一枝蒿氨基酸的高效液相色谱分析[J].食品研究与开发，200,7(11):119-121.
[23]李默，包瑛，王坤，等.新疆一枝蒿多糖的结构鉴定及清除自由基活性[J].中央民族大学学报(自然科学版),2018,27(4):86-95.
[24]Liu L,Wang H,Liu L,et al.Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain[J].Viruses,2024,16(7):1151-1151.
[25]李治建，古力娜·达吾提，斯拉甫·艾白.一枝蒿有效部位抗乙肝病毒作用研究[J].中药药理与临床，2012,28(3):149-150.
[26]Lu C,Yong J .Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary;Anti-influenza Viral Activity[J].Current Pharmaceutical Design,2024,30(18):1398-1403.
[27]斯拉甫，阿不都热依木，古力娜，等.新疆一枝蒿提取物保肝作用的实验研究[J].中国中西医结合杂志，2002,(2):126-128.
[28]Cai X,Kuerban M,Hasimu H,et al.Bioactive compounds from Dichloromethane extract of Artemisia rupestris L.alleviates CCl4/ConA-induced acute liver injury by inhibiting PI3K-AKT pathway[J].Journal of ethnopharmacology,2024:333118416.
[29]盛萍.新疆一枝蒿体外抗肿瘤物质基础及制备工艺研究[D].新疆：新疆医科大学，2008.
[30]Zhang S,Cai X,Khan G J,et al.Exploring the molecular mechanism of Artemisia rupestris L.for the treatment of hepatocellular carcinoma via PI3K/AKT pathway[J].Ethnopharmacol,2024:322117572.
[31]韩梦婷.一枝蒿提取物对胃食管反流致气道高反应的药效作用及机制研究[D].乌鲁木齐：新疆医科大学，2019.
[32]Wang C,Wang B.Effect of Artemisia Rupestris L.Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats[J].Evidence-Based Complementary And Alternative Medicine,2020:2528617.
[33]李君，张玲，赵婧，等.新疆一枝蒿黄酮提取物抗氧化活性分析[J].光谱实验室，2012,29(4):2218-2221.
[34]肖威，斯拉甫·艾白，李治建.新疆一枝蒿抗炎作用研究[J].时珍国医国药，2008,19(12):2836-2838.
[35]蔡晓翠，毛艳，贺金华，等.新疆一枝蒿不同极性部位体外抗炎作用的谱-效关系分析[J].药物分析杂志，2019,39(9):1580-1589.
[36]方美珠，晁群芳，兰雁，等.新疆一枝蒿提取物抑菌作用的研究[J].食品科技，2011,(1):160.
[37]Li Q,Weng X,Zhao B,et al.Immunoregulatory properties of the cultivated Artemisia rupestris L.polysaccharide as a potential adjuvant[J].Carbohydrate Polymers,2022:291119525.
[38]Wang D,Cao H,Li J,et al.Adjuvanticity of aqueous extracts of Artemisia rupestris L.for inactivated foot-and-mouth disease vaccine in mice[J].Research in Veterinary Science,2019:124191-124199.
[39]薛丹婷，李红玲，王泳鑫，等.新疆一枝蒿不同溶剂提取物治疗Ⅰ型过敏的药效学比较研究[J].时珍国医国药，2012,23(10):2633-2634,2637.
[40]王泳鑫，徐建国，李红玲，等.新疆一枝蒿治疗I型过敏的药效学及其作用机制研究[J].新疆中医药，2013,31(5):124-127.
[41]陈路路，王中华，周帜，等.基于液相色谱-串联质谱技术的新疆一枝蒿植物代谢组学分析方法研究[J].分析化学，2018,46(5):735-742.
[42]王纪阳，周帜，谢冰，等.基于代谢组学的新疆一枝蒿生长关键成分研究[J].分析化学，2023,51(3):390-396.
[43]孙坤坤，王加锋.辛味药药性理论及归经应用[J].山东中医药大学学报，2021,45(4):458-461.
[44]周复辉，易增兴，罗亨凡.辛味中药化学成分的分析[J].安徽农业科学，2006,34(12):2760,2782.
[45]穆合拜提·木合塔尔，赵丰，买吾兰江·买提努尔.HPLC-DAD同时检测一枝蒿药材中的5种化学成分研究[J].中国新药杂志，2021,30(17):1621-1626.
[46]刘明娟，李凯琳，张敏，等.基于UHPLC-Q-Exactive Orbitrap MS的复方一枝蒿颗粒化学成分快速鉴定[J].中国现代中药，2024,26(3):507-517.
[47]严雅慧，吴涛，陈菊，等.乃孜来颗粒中化学成分的UHPLC-Q-Orbitrap-MS分析[J].中国实验方剂学杂志，2021,27(21):156-166.
[48]刘燕，王雪，姚华，等.蒿蓝感冒颗粒抗甲型流感病毒作用的研究[J].中药药理与临床，2014,30(3):132-135.
基本信息:
DOI：10.13412/j.cnki.zyyl.20250318.006
中图分类号:R284.1
引用信息:
[1]阿地娜·阿不都艾尼,毛艳,张思蓉.新疆一枝蒿质量标志物预测分析[J].中药药理与临床,2025,41(08):106-114.DOI:10.13412/j.cnki.zyyl.20250318.006.
基金信息:
新疆维吾尔自治区自然科学基金-杰出青年项目(编号：2021D01E25); 新疆维吾尔自治区重点研发计划项目(编号：2023B03012-2)