中药药理与临床

本文以对鲜酵母所致发热大鼠的解热效应为指标探讨了麻黄汤、银翘散等四个辛温和辛凉解表代表方剂的药物动力学参数,结果表明麻黄汤的最小起效剂量为0.18g/kg,作用期为6.4小时,体内生物相当药量的消除半衰期为1.11小时;桂枝汤相应为0.42g/kg、10.6和1.34小时;银翘散相应为0.43g/kg、8.5和1.19小时;桑菊饮相应为0.45g/kg、12.2和2.24小时。银翘散和桑菊饮吸收半衰期分别为0.54小时和0.8小时,达峰时间分别为1.29和1.77小时。应用鲜酵母致热模型作时间一效应观察时,给药剂量宜用相当于人的临床等效剂量,药效测定点选择发热峰值时为妥。

Considering the antipyretic effect of Mahuang-Tang, Quizhi Tang, Yinqiao-San and Sangju-Yin be provided with the dose-effect and time-effect relationships, pharmacodynam-ics and pharmacokmetics of those traditional Chinese prescriptions were studied in mice. The results showed that the minimal effective dose in p.o., action period of clinical equivalent does, effect half-life time (t1/2(ED)), half-life time for elimination effective dose (t1/2(ED)) was 0.177g/kg, 6.39h, 1.48h, and 1.1h in Mahuang-Tang, and 0.416g/kg, 10. 62h, 2.96h, 1.34h in Quizhi Tang, 0.43g/kg, 8.49h, 1.93h, 1.19h in Yinqiao-San, 0.44 g/kg, 12.15h, 3.88h, 2.24h in Sangju-Yin, respectively. The half-life time for absorption and peak time was 0.54h and 1.29h in Yinqiao San, and 0.8h, 1.77h in Sangju-Yin, respectively.