中药药理与临床

目的 :研究薄荷油的药理作用。方法 :采用大鼠利胆、体外溶石、离体平滑肌、角叉菜胶致炎等方法。结果 :薄荷油12 0、6 0、30mg/kg十二指肠给药 ,对大鼠有明显的利胆作用 ,并能轻度增加胆汁中胆汁酸的排出量。 5、0 5、0 0 5mg/L在 4～ 5周内对胆固醇结石、胆色素结石无明显溶解作用。薄荷油对豚鼠离体回肠有一定的抑制作用 ,并能拮抗组胺和乙酰胆碱引起的回肠痉挛。对角叉菜胶致大鼠足肿胀和醋酸致小鼠扭体反应有一定的抑制作用 ,但对二甲苯致小鼠耳肿胀、小鼠棉球肉芽肿增生、小鼠温浴致痛反应潜伏期无明显影响。小鼠igMTD >40 0 0mg/kg ,ipLD50 为 114 4 9± 78 5 (10 6 9 1～ 12 2 6 0 )mg/kg。 结论 :薄荷油有明显的利胆作用、一定的解痉作用和较弱的抗炎镇痛作用 ,体外无溶石作用。

Objective: To study the pharmacologic effects of peppermint oil. Method: The methods of choleretic test, dissolving gallstone in vitro, isolated smooth muscle test, acute inflammation induced by carrageenin were used. Result: Peppermint oil 120、60、30 mg/kg giving into duodenum could significantly increase the secretion volume of bile in rat, and slightly increase the concentration of cholic acid in bile. Peppermint oil 5, 0.5 and 0.05mg/L has no dissolving effect on cholesterol gallstone and bile pigment gallstone in 4～5 weeks. Peppermint oil could inhibit contraction of isolated ileum and antagonize the contraction induced by histamine and acetylcholine in guinea pigs. It could also suppress paw edema induced by carrageenin in rat and writhing induced by acetic acid in mice, but has no effect on the ear swelling caused by dimethylbenzene and cotton granulation hyperplasia and latent period of pain reaction in tail immersion test in mice. The MID>4000mg/kg as single oral doses and LD 50 was 1144.9±78.5 (1069.1～1226.0) mg/kg when administered by intraperitoneal injection to mice. Conclusion: Peppermint oil has the effects of choleretic and relieve smooth muscle spasm, and the effects of anti-inflammation and analgesia were weak, but has no dissolving effect on gallstone in vitro.