中药药理与临床

在心血管疾病(CVDs)的发病机制中多种细胞死亡形式如凋亡、坏死、焦亡、自噬和铁死亡等在心脏发育和心血管稳态中是长期存在并且是必不可少的。铁死亡是一种新型的程序性细胞死亡，由铁依赖性脂质过氧化物的积累引起。铁死亡已被证明参与了心血管疾病的发生和发展过程，在心肌病、心肌梗死(MI)、缺血/再灌注损伤(IRI)、心力衰竭(HF)和动脉粥样硬化(AS)中起着重要作用，调节细胞与铁死亡之间的平衡可能成为药物干预疾病的重要靶点。本文主要围绕铁死亡在心血管疾病中的调控机制及其中医药研究方面进行探讨，为靶向铁死亡作为心血管疾病的预防和治疗提供新的科学依据与策略。

Various forms of cell death, such as apoptosis, necrosis, pyroptosis, autophagy, and ferroptosis, are the underlying causes of cardiovascular diseases(CVDs). Ferroptosis is a novel form of programmed cell death caused by the accumulation of iron-dependent lipid peroxides. It has been verified to be involved in the occurrence and development of CVDs, such as cardiomyopathy, myocardial infarction(MI),ischemia/reperfusion injury(IRI),heart failure(HF),and arteriosclerosis(AS). Drugs regulating the balance between cells and ferroptosis may be effective for these diseases. Traditional Chinese medicine has long been applied to CVDs with unique advantages, which regulates ferroptosis-related pathways and provides novel therapies for such diseases. This paper mainly discusses the regulatory mechanism of ferroptosis in CVDs and related research in traditional Chinese medicine, which is expected to lay a basis and provide strategies for the prevention and treatment of CVDs by targeting ferroptosis.