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肾纤维化是各种慢性肾脏病进展至终末期肾衰竭不可避免的共同病理过程，严重危害着人类健康。大量研究证实TGF-β1/SMAD信号通路在肾纤维化的发展中发挥着重要作用。中医药在防治肾纤维化方面具有独特优势和良好前景，其中有不少可靶向调节TGF-β1/SMAD信号通路的单味中药及其有效成分或其复方。本文就TGF-β1/SMAD信号通路在慢性肾脏病肾纤维化中的作用以及近年来中医药靶向TGF-β1/SMAD信号通路防治肾纤维化研究进展作简要综述，以期为临床中医药防治肾纤维化提供参考。
Abstract：Renal fibrosis is an inevitable common pathological process of various chronic kidney diseases progressing to end-stage renal failure, which seriously endangers human health. A large number of studies have confirmed that TGF-β1/Smad signaling pathway plays an important role in the development of renal fibrosis. Traditional Chinese medicine(TCM) has unique advantages and good prospects in the prevention and treatment of renal fibrosis, and there are many single Chinese medicines and their active components or the compound formulas that can target and regulate the TGF-β1/Smad signaling pathway. This paper reviewed the role of TGF-β1/Smad signaling pathway in renal fibrosis of chronic kidney diseases and summarized the research progress of TCM targeting the pathway in preventing and treating renal fibrosis in recent years, in order to provide reference for the clinical prevention and treatment of renal fibrosis with TCM.
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基本信息:
DOI：10.13412/j.cnki.zyyl.20220323.003
中图分类号:R285
引用信息:
[1]孙倩,李姗姗,杨少宁,等.中医药靶向TGF-β1/SMAD信号通路防治肾纤维化研究进展[J].中药药理与临床,2023,39(01):118-124.DOI:10.13412/j.cnki.zyyl.20220323.003.
基金信息:
国家自然科学基金(编号：82174366); 陕西省中医药管理局(编号：2021-GJ-LC022); 陕西省科技厅社发攻关一般项目(编号：2017SF-298); 西安市科技计划项目[编号：2019115613YX011SF044(9)]
2022-03-24
2022-03-24
2022-03-24