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贯叶连翘是一种多年生草本植物,入药部位为全草或带根全草,具有清热解毒,收敛止血,利湿等功效。贯叶连翘中主要含有黄酮类、苯并二蒽酮类、间苯三酚类等化学成分,这些成分表现出良好的抗炎、抗病毒、抗肿瘤、抗抑郁、抗菌以及保肝、保护神经细胞等药理活性,被广泛应用于制药与临床。同时对贯叶连翘不同的抗病机制进行研究,发现其作用机制较为复杂,且部分机制尚未明确。本文对贯叶连翘的药理作用及作用机制相关文献进行整理分析,并系统综述,以期为贯叶连翘后续的深入研究和利用前景提供参考。
Abstract:Hypericum perforatum L. is a perennial herbaceous plant, with the medicinal part of the whole herb or the whole herb with the root. It has the effects of Qingre(清热),Jiedu(解毒),Shoulian(收敛),Zhixue(止血),and Lishi(利湿). H. perforatum mainly contains flavonoids, naphthodianthrones, and phloroglucinol. These components show anti-inflammatory, anti-viral, anti-tumor, antidepressant, antibacterial, and other pharmacological activities, and are potent in protecting the liver and nerve cells. They are widely used in drug production and clinical application. As revealed by the exploration of the mechanisms of H. perforatum against diseases, the mechanisms were complex and some mechanisms remained unclear. The present study systematically analyzed and reviewed the pharmacological effects and mechanisms of H. perforatum to provide references for the follow-up in-depth research and application prospect of H. perforatum.
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基本信息:
DOI:10.13412/j.cnki.zyyl.20220601.007
中图分类号:R285
引用信息:
[1]盛可心,王昊冉,徐凌川,等.贯叶连翘药理作用及其机制研究新进展[J].中药药理与临床,2023,39(03):117-122.DOI:10.13412/j.cnki.zyyl.20220601.007.
基金信息:
国家中医药管理局全国中药资源普查项目(编号:GZY-KJS-2018-004); 山东省中医药管理局中医药科技发展计划项目(编号:2019-0976)
2022-06-02
2022-06-02
2022-06-02