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天麻是我国传统名贵中药,具有防治老年痴呆症、焦虑症、抑郁症、中风和癫痫,改善记忆,延缓衰老等功效。天麻中天麻素等主要酚类活性成分表现出良好的中枢神经药理作用,可以用于防治中枢神经系统疾病。本文例举了天麻的主要酚类成分,阐明了天麻素、4-羟基苯甲醇和巴利森苷的药物代谢动力学特征,总结了天麻素、4-羟基苯甲醇、4-羟基苯甲醛、香草醇、香草醛和巴利森苷等对中枢神经系统疾病如阿尔兹海默病、帕金森病、焦虑症、抑郁症、脑缺血和癫痫的临床前药理作用及机制。
Abstract:Gastrodia elata Blume is the famous traditional Chinese medicine that has been used for the treatment of Alzheimer's disease, anxiety, depression, stoke and epilepsy. It also shows anti-aging and memory improving effect. Gastrodin and other main phenolic components in Gastrodia elata Blume shows pharmacological effects on the central nervous system and can be applied on the treatment of central nervous system disorders. In this article, we summarized gastrodin and other main phenolic components in Gastrodia elata Blume. Also we did pharmacokinetic studies on gastrodin, 4-hydroxybenzyl alcohol and parishin. We studied the beneficial effects and the mechanisms of gastrodin, 4-hydroxybenzyl alcohol, 4-hydroxybenzaldehyde, vanillyl alcohol, vanillin and parishin in central nervous system disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, cerebral ischemia and epilepsy.
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基本信息:
DOI:10.13412/j.cnki.zyyl.2019.02.039
中图分类号:R285;R284
引用信息:
[1]张成宸,石京山.天麻的酚类成分及其中枢神经药理作用研究进展[J].中药药理与临床,2019,35(02):167-174.DOI:10.13412/j.cnki.zyyl.2019.02.039.
2019-04-15
2019-04-15