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2型糖尿病是由胰岛β细胞功能障碍和(或)胰岛素抵抗引起的以慢性高血糖为主要特征的代谢性疾病,因其目前患病率的日益增加,使得防治2型糖尿病已然成为急需攻破的重要难题。近年来,中药以有效性、多靶点、毒副作用低的特点成为研究的热点,其中有关人参提取物及皂苷类成分抗炎抗菌、抗肿瘤、抗氧化以及对心血管系统、中枢神经系统的研究较多,而对改善2型糖尿病等代谢性疾病作用机制的研究相对较少。本文就近年来人参提取物及皂苷类成分对2型糖尿病作用机制的研究情况展开综述,并指出存在问题及发展趋势,以期对人参作为2型糖尿病潜在防治药物的早期临床应用提供参考依据。
Abstract:Type 2 diabetes mellitus(T2DM) is a metabolic disease characterized by chronic hyperglycemia caused by islet β cell dysfunction and/or insulin resistance, and because of the increasing prevalence, the prevention and treatment of T2DM have become an important task to be conducted. In recent years, Chinese medicine has become a research hot spot because of its high efficacy, multiple targets, and few toxic and side effects. The anti-inflammatory, anti-bacterial, anti-tumor, anti-oxidative effects of GINSENG RADIX ET RHIZOMA(GR) extract and ginsenosides, as well as their effects on the cardiovascular system and central nervous system, were frequently investigated, but there were few studies on the mechanism of GR extract and ginsenosides in improving metabolic diseases such as T2DM. The present study reviewed the recent research on the mechanism of GR extract and ginsenosides on T2DM,pointed out the existing problems, and clarified the development trend to provide references for early clinical application of GR as a potential preventive and therapeutic agent for T2DM.
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基本信息:
DOI:10.13412/j.cnki.zyyl.20220506.002
中图分类号:R284.1;R285
引用信息:
[1]张金山,刘艳,张立会,等.人参提取物及皂苷类成分对2型糖尿病作用机制的研究进展[J].中药药理与临床,2023,39(07):114-119.DOI:10.13412/j.cnki.zyyl.20220506.002.
基金信息:
国家自然科学基金(编号:81560605); 吉林省科技厅科技发展计划项目青年科研基金项目(编号:20150520148JH)
2022-05-07
2022-05-07
2022-05-07