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痛风性关节炎是一种以嘌呤代谢异常或尿酸排泄障碍引起的尿酸钠晶体沉积于关节及周围组织导致的疾病,临床症状表现为关节红、肿、热、痛,严重的会影响肢体功能障碍,严重影响正常生活。因此研究痛风性关节炎的发病机制,以寻找有效的药物作用靶点靶向治疗痛风性关节炎具有一定的现实意义。大量研究结果已经证实多种细胞信号转导途径参与了痛风性关节炎的发生与发展,包括Toll受体信号通路、NLRP3炎性体信号通路、NLRP6炎性体信号通路等。本文按照与痛风性关节炎发病机制的不同通路进行归纳分类并且展开综述,为痛风性关节炎发病机制的研究提供一定的理论依据。
Abstract：Gouty arthritis is a disease caused by the deposition of sodium urate crystals in joints and surrounding tissues, and the deposition of sodium urate crystals come from the abnormal purine metabolism or uric acid excretion disorder. The clinical symptoms include red, swollen, hot and painful joints, which will seriously affect the limb function and normal life. Therefore, it is of practical significance to study the pathogenesis of gouty arthritis in order to find effective drug targets for targeted therapy of gouty arthritis. A large number of studies have confirmed that many cellular signal transduction pathways are involved in the occurrence and development of gouty arthritis, including Toll receptor signaling pathway, NLRP3 inflammasome signaling pathway, NLRP6 inflammasome signaling pathway. In CNKI, Wanfang, Weipu, SCI-hub and other databases, 85 related literatures in recent three years were searched with "gouty arthritis" and "Signal path" as keywords, 50 English literatures in recent three years were searched with "Gouty Arthritis" and "Signal Path" as keywords, and 53 valid Chinese and English literatures were obtained through screening. The screened literatures were classified and summarized according to the different pathways of pathogenesis of Gouty Arthritis, and provide theoretical basis for the research gouty arthritis pathogenesis.
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基本信息:
DOI：10.13412/j.cnki.zyyl.20210202.009
中图分类号:R589.7
引用信息:
[1]欧阳香,丁婷,杨海艳,等.痛风性关节炎发病机制相关信号通路的研究进展[J].中药药理与临床,2021,37(04):234-240.DOI:10.13412/j.cnki.zyyl.20210202.009.
基金信息:
国家自然科学基金项目(编号：82060757); 国家重点研发计划项目(编号：2019YFC1712300); 江西省教育厅科学技术研究项目重点项目(编号：GJJ190632); 江西省中医药管理局科技计划项目(编号：2019A004)
2021-02-03
2021-02-03
2021-02-03