中药药理与临床

参考文献

[1]Tajuddin,Ahmad S,Latif A,Qasmi I A,et al.Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt.(nutmeg) and Syzygium aromaticum (L) Merr.& Perry.(clove) in male mice:a comparative study[J].BMC Complementary and Alternative Medicine,2003,3(1):6-11.

[2]Tajuddin,Ahmad S,Latif A,et al.An experimental study of sexual function improving effect of Myristica fragrans Houtt.(nutmeg)[J].BMC Complementary and Alternative Medicine,2005,(5):16.

[3]Rukayadi Y,Kim K H,Hwang J K.In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt.against oral primary colonizer bacteria[J].Phytotherapy Reseach,2010,22(3):308-312.

[4]Gazzani G,Daglia M,Papetti A.Food components with anticaries activity[J].Current Opinion in Biotechnology,2012,23(2):153-159.

[5]Ghorbanian D,Ghasemi-Kasman M,Hashemian M,et al.Myristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model[J].Iranian Journal of Pharmaceutical Research:IJPR,2019,18(2):812.

[6]Abdul Rahman M A A,Mohd Noor M H,Mustafa M Z,et al.Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt.essential oil in the epileptic rat model[C].6th Proceedings of the Seminar on Veterinary Sciences,2011:30-36.

[7]Parle M,Dhingra D,Kulkarni S K.Improvement of mouse memory by Myristica fragrans seeds[J].Journal of Medicinal Food,2004,7(2):157-161.

[8]Sharma A,Dhingra D.Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice[J].Journal of Medicinal Food,2006,9(1):84-89.

[9]Moinuddin,Devi K,Khajuria D K.Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats[J].Avicenna Journal of Phytomedicine,2012,2(2):72-78.

[10]Janssens J,Laekeman G M,Pieters L A C,et al.Nutmeg oil:identification and quantitation of its most active constituents as inhibitors of platelet aggregation[J].Journal of Ethnopharmacology,1990,29(2):179-188.

[11]Grover J K,Khandkar S,Vats V,et al.Pharmacological studies on Myristica fragrans--antidiarrheal,hypnotic,analgesic and hemodynamic (blood pressure) parameters[J].Methods Find Exp Clin Pharmacol,2002,24(10):675-680.

[12]Motilal S,Maharaj R G.Nutmeg extracts for painful diabetic neuropathy:a randomized,double-blind,controlled study[J].Journal of Alternative & Complementary Medicine,2013,19(4):347-352.

[13]Zhang W K,Tao S,Li T,et al.Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo[J].Food & nutrition research,2016,(60):30849.

[14]Han K L,Choi J S,Lee J Y,et al.Therapeutic Potential of Peroxisome Proliferators-Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes[J].Diabetes,2008,57(3):737-745.

[15]Sailesh,K.S.;Padmanabha.A comparative study of the anti diabetic effect of oral administration of cinnamon,nutmeg and peppermint in wistar albino rats[J].International Journal of Health Sciences & Research,2014,4(2),61-67.

[16]Lestari K,Diantini A,Barliana M I,et al.Potential Natural Dual Agonist PPARa/y-induced Antidiabetic and Antidyslipidemic properties of safrole-free Nutmeg seed (Myristica fragrans Houtt) extract[J].The Natural Products Journal,2019,9(3):248-253.

[17]Ha M T,Vu N K,Tran T H,et al.Phytochemical and pharmacological properties of Myristica fragrans Houtt.:an updated review[J].Archives of Pharmaceutical Research,2020,43(11):1067-1092.

[18]Yimam M,Jiao P,Hong M,et al.Hepatoprotective activity of an herbal composition,MAP,a standardized blend comprising myristica fragrans,astragalus membranaceus,and poria cocos[J].Journal of Medicinal Food,2016,19(10),953-960

[19]Yang X N,Liu X M,Fang,J H,et al.PPARα mediates the hepatoprotective effects of nutmeg[J].Journal of Proteome Research.2018,(17),1887-1897.

[20]Sohn J H,Han K L,Kim J H,et al.Protective effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation[J].Biological and Pharmaceutical Bulletin,2008,31(2):273-277.

[21]Saiki P,Kawano Y,Nakajima Y,et al.Novel and Stable Dual-Color IL-6 and IL-10 Reporters Derived from RAW 264.7 for Anti-Inflammation Screening of Natural Products[J].International Journal of Molecular Sciences,2019,20(18):4620-4627.

[22]Zhao W,Song F,Hu D,et al.The Protective Effect of Myristica fragrans Houtt.Extracts Against Obesity and Inflammation by Regulating Free Fatty Acids Metabolism in Nonalcoholic Fatty Liver Disease[J].Nutrients,2020,12(9):2507-2526.

[23]Piaru S P,Mahmud R,Majid A M S A,et al.Chemical composition,antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia[J].Journal of the Science of Food and Agriculture,2012,(92):593-597

[24]Hussain S P,Rao A R.Chemopreventive action of mace (Myristica fragrans,Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice[J].Cancer Letters,1991,56(3):231-234.

[25]Zhang C,Qi X ,Shi Y ,et al.Estimation of Trace Elements in Mace (Myristica fragrans Houtt) and Their Effect on Uterine Cervix Cancer Induced by Methylcholanthrene[J].Biological Trace Element Research,2012,149(3):431-434.

[26]Abraham J,Chakraborthy P,Lavanya P.Bioactivity of Myristica fragrans methanol extract[J].World Journal of Pharmaceutical Research,2015,4(9):1145-1147.

[27]Akinboro A,Mohamed K B,Asmawi M Z,et al.Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays[J].Drug and Chemistry Toxicology,2012,35(4):412-422.

[28]Cinthura C.Genotoxicity Analysis of Mace (Myristica fragrans) on Oral Cancer Cell Line by DNA Fragmentation[J].Journal of Pharmaceutical Sciences Research,2017,9(2):205-207.

[29]Yuliana N D,Iqbal M,Jahangir M,et al.Screening of selected Asian spices for anti obesity-related bioactivities[J].Food Chemistry,2011,126(4):1724-1729.

[30]Nguyen P H,Le T V T,Kang H W,et al.AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect[J].Bioorganic & Medicinal Chemistry Letters,2010,20(14):4128-4131.

[31]Agl S,Bkf S,Bsn M,et al.An in vitro study reveals the anti-obesity effects of 7- methoxy-3-methyl-5-((E)-prop-1-enyl)-2-(3,4,5-trimethoxyphenyl)-2,3-dihydrobenzofuran from Myristica fragrans[J].European Journal of Pharmacology,2021,891(15):173686.

[32]Jain S,Raja W.Evaluation of Antibacterial Activity of Myristica Fragrans Seed Extract Using Disk Diffusion Method[J].Asian Journal of Pharmaceutical and Biological Research,2019,7(3):77-83.

[33]Marketa H,Klara U,Ivo D,et al.Anti-staphylococcal activity,cytotoxicity,and chemical composition of hexane extracts from arils and seeds of two Samoan Myristica[J].Brazilian Journal of Microbiology,2021,(139):1-5

[34]Gupta A D,Bansal V K,Babu V,et al.Chemistry,antioxidant and antimicrobial potential of nutmeg (Myristica fragrans Houtt)[J].Journal of Genetic Engineering and Biotechnology,2013,11(1):25-31.

[35]Valente V M M,Jham G N,Jardim C M,et al.Major antifungals in nutmeg essential oil against Aspergillus flavus and A.ochraceus[J].Journal of Food Research.2015,4 (1):51-57.

[36]Matulyte I,Jekabsone A,Jankauskaite L,et al.The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient:Antioxidant,Antibacterial,and Anti-inflammatory Activity[J].Foods,2020,9(1):37.

[37]Mahesh Pal,Manjoosha Srivastava.Composition and anti-microbial activity of essential oil of Myristica fragrans from Andaman Nicobar Island[J].International Journal of Pharmaceutical and Life Sciences(IJPLS),2011,2(10):1115- 1117

[38]Jung W C,Jang Y S,Hieu T T,et al.Toxicity of Myristica fragrans seed compounds against Blattella germanica (Dictyoptera:Blattellidae)[J].Journal of Medical Entomology,2007,44(3):524-529.

[39]Park I K,Kim J N,Lee Y S,et al.Toxicity of plant essential oils and their components against Lycoriella ingenua (Diptera:Sciaridae)[J].Journal of Economic Entomology,2008,101(1):139-144.

[40]Chaubey M K.Fumigant toxicity of essential oils from some common spices against pulse beetle,Callosobruchus chinensis (Coleoptera:Bruchidae)[J].Journal of Oleo Science,2008,57(4):171-179.

[41]Pillai S,Mahmud R,Cai W,et al.Anti-Parasitic Activity of Myristica Fragrans Houtt[C].Essential Oil Against Toxoplasma Gondii Parasite// 2012 3rd International Conference on Biotechnology and Food Science,2012.■wiech,Iwona Po■.Comparison of the insecticidal effectiveness of synthetic and natural myristicin against housefly (Musca domestica L.) and oriental cockroach (Blatta orientalis)[J].Chemik Science-Technique-Market,2013,11(67):645-647.

[43]Du S S,Yang K,Wang C F,et al.Chemical Constituents and Activities of the Essential Oil fromMyristica fragransagainst Cigarette BeetleLasioderma serricorne[J].Chemitry& Biodiversity,2014,11(9):1449-1456.

[44]Wagan T A,Wang W,Hua H,et al.Chemical Constituents and Toxic,Repellent,and Oviposition-Deterrent Effects of Ethanol-Extracted Myristica fragrans (Myristicaceae) Oil on Bemisia tabaci (Hemiptera:Aleyrodidae)[J].Florida Entomologist,2017,100(3):594-601.

[45]Wong C,Crystal K,Coats J.Three Molecules Found in Rosemary or Nutmeg Essential Oils Repel Ticks (Dermacentor variabilis) more Effectively than DEET in a Non‐human Assay[J].Pest Management Science,2020,77(3):1348-1454.

[46]Jaiswal P,Singh D K,Singh V K,et al.Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt.in the Nervous Tissue of Snail Lymnaea acuminata[J].Enzyme Research,2010,(5):1-6.

[47]Jan M,Faqir F,Mughal M A.Comparison of effects of extract of Myristica fragrans and verapamil on the volume and acidity of carbachol induced gastric secretion in fasting rabbits[J].Journal of Ayub Medical College Abbottabad,2005,17(2):69-71.

[48]Cao G Y,Xu W,Yang X W,et al.New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production[J] Food Chemistry,2015,173(15):231-7.

[49]Grover J K,Khandkar S,Vats V,et al.Pharmacological studies on Myristica fragrans--antidiarrheal,hypnotic,analgesic and hemodynamic (blood pressure) parameters[J].Methods Find Exp Clin Pharmacol,2002,24(10):675-680.

[50]Han J H,Park D H,Jung Y W,et al.Anti-platelet activity studies on compounds of neolignan from Myristica fragrans[J].Planta Medica,2016,81(S1):S1-S381.

[51]Reynoard J,Torrents R,Domange B,et al.Nutmeg poisoning:Ten years (2008-2018) of experience from the Marseille Poison Control Center[J].La Presse Médicale,2019,48(9):994-996.

[52]Hawes M H.Hepatotoxicosis in cattle associated with consumption of Punica granatum (pomegranate)[J].Austral Journal of Veterinary Sciences,2018,96(10):408-410

[53]Stein U ,Greyer H ,Hentschel H .Nutmeg (myristicin) poisoning — report on a fatal case and a series of cases recorded by a poison information centre[J].Forensic Science International,2001,118(1):87-90.

[54]Beckerman B,Persaud H.Nutmeg overdose:Spice not so nice[J].Complementray Therapies in Medcine,2019,(46):44-46.

[55]Gupta A D ,Rajpurohit D .Antioxidant and Antimicrobial Activity of Nutmeg ( Myristica fragrans )[M].Nuts and Seeds in Health and Disease Prevention,Academic Press,2011:831-839.

[56]Cao Z,Xia W,Zhang X,et al.Hepatotoxicity of nutmeg:A pilot study based on metabolomics[J].Biomedicine & Pharmacotherapy,2020,(131):110780.

[57]Pflaum T,Hausler T,Baumung C,et al.Carcinogenic compounds in alcoholic beverages:An update[J].Archives of Toxicology,2016,90(10):2349-2367.

[58]Al-Malahmeh A J,Al-Ajlouni A M,Wesseling S,et al.Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto[J].Toxicology Reports,2017,(4):1-8.

[59]Muchtaridi,Subarnas A,Apriyantono A,et al.Identification of Compounds in the Essential Oil of Nutmeg Seeds (Myristica fragrans Houtt.) That Inhibit Locomotor Activity in Mice[J].International Journal of Molecular Sciences,2010,11(11):4771-4781.

[60]Nutmeg[DB/OL].https://www.drugs.com.

[61]Demetriades A K,Wallman P D,McGuiness A,et al.Low cost,high Risk:Accidental Nutmeg Intoxication[J].Western Journal of Emergency Medicine,2003,22(3):223-225.

[62]Bizzarro A,Iannucci F,Tolino A,et al.Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH[J].Clinical and Experimental Obstetrics & Gynecology,1980,7(2):108-111.

[63]Masala A,Alagna S,Devilla L,et al.Muscarinic receptor blockade by pirenzepine:effect on prolactin secretion in man[J].Journal of Endocrinological Investigation,1982,(5):53-55.

[64] Zava D T,Dollbaum C M,Blen M.Estrogen and progestin bioactivity of foods,herbs,and spices[J].Proceedings of The Society for Experimental Biology and Medicine.1998,217(3):369-378.

[65]Lee B K,Kim J H,Jung J W,et al.Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells[J].Toxicology Letters,2005,157(1):49-56.

[66]Chirathaworn C,Kongcharoensuntorn W,Dechdoungchan T,et al.Myristica fragrans Houtt.methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation[J].Journal of the Medical Association of Thailand = Chotmaihet thangphaet,2007,90(11):2422-2428.

[67]Célia Martins,Doran C,António Laires,et al.Genotoxic and apoptotic activities of the food flavourings myristicin and eugenol in AA8 and XRCC1 deficient EM9 cells[J].Food & Chemical Toxicology,2011,49(2):385-392.